The Laboratory of User Interaction and Software Engineering (LoUISE ) was created in 2000 and during the last years has aimed his research activities towards Human-Computer Interaction discipline. Its goals have been always centred in enhancing the quality of interactive systems. With this aim it has stood on other branches of knowledge such as Software Engineering, Artificial Intelligence or the Design of Control Systems for the development of cyber-physical systems. Nowadays the group consists of ten researchers belonging to the University of Castilla-La Mancha (UCLM). Throughout the trajectory of the group, the laboratory has included a high number of researchers working both in Spain and abroad. Regarding the research lines, they have changed, currently focusing in health area.