
El Centro Regional de Investigaciones Biomédicas (CRIB) es un centro universitario de investigación de la Universidad de Castilla-La Mancha creado en julio del año 2000 con el objetivo de fomentar la investigación biomédica en nuestra región.


El CRIB participa en la organización e impartición de docencia oficial de postgrado de calidad en biomedicina: el Máster Universitario en Biomedicina Experimental y el Programa de Doctorado en Ciencias de la Salud (Verificado según R.D. 99/2011) Más info
Últimas publicaciones

- Candida parapsilosis colony morphotype forecasts biofilm formation of clinical isolates. Gomez-Molero E, De-la-Pinta I, Fernandez-Pereira J, Groß U, Weig M, Quindós G, De Groot PWJ, Bader O. J Fungi (Basel). 2021 Jan 7;7(1):E33. doi: 10.3390/jof7010033.
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Identification of Candida auris and related species by multiplex PCR based on unique GPI protein-encoding genes. Alvarado M, Bartolomé Álvarez J, Lockhart SR, Valentín E, Ruiz-Gaitán AC, Eraso E, De Groot PWJ. Mycoses. 2021 Feb;64(2):194-202. doi: 10.1111/myc.13204.
- p38β (MAPK11) mediates gemcitabine-associated radiosensitivity in sarcoma experimental models. Pascual-Serra R, Fernández-Aroca DM, Sabater S, Roche O, Andrés I, Ortega-Muelas M, Arconada-Luque E, Garcia-Flores N, Bossi G, Belandia B, Ruiz-Hidalgo MJ, Sánchez-Prieto R. Radiother Oncol. 2020 Dec 11;156:136-144. doi: 10.1016/j.radonc.2020.12.008.
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Candida duobushaemulonii: an old but unreported pathogen. Jurado-Martín I, Marcos-Arias C, Tamayo E, Guridi A, De Groot PWJ, Quindós G, Eraso E. J Fungi (Basel). 2020 Dec 17;6(4):374. doi: 10.3390/jof6040374.
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MicroMundo upside down: targeted searching for antibiotics-producing bacteria from soil with reverse antibiosis approaches. Alvarado M, Clemente-Casares P, Moreno DA, De Groot PWJ. Front Microbiol. 2020 Oct 15;11:577550. doi: 10.3389/fmicb.2020.577550.
- p38β and Cancer: The Beginning of the Road. Roche O, Fernández-Aroca DM, Arconada-Luque E, García-Flores N, Mellor LF, Ruiz-Hidalgo MJ, Sánchez-Prieto R. Int J Mol Sci. 2020 Oct 12;21(20):7524. doi: 10.3390/ijms21207524. PMID: 33053909.
- NOTCH3 signaling is essential for NF-κB activation in TLR-activated macrophages. López-López S, Monsalve EM, Romero de Ávila MJ, González-Gómez J, Hernández de León N, Ruiz-Marcos F, Baladrón V, Nueda ML, García-León MJ, Screpanti I, Felli MP, Laborda J, García-Ramírez JJ, Díaz-Guerra MJM. Sci Rep. 2020 Sep 9;10(1):14839. doi: 10.1038/s41598-020-71810-4. PMID: 32908186
- NOTCH Receptors and DLK Proteins Enhance Brown Adipogenesis in Mesenchymal C3H10T1/2 Cells.
Rodríguez-Cano MM, González-Gómez MJ, Sánchez-Solana B, Monsalve EM, Díaz-Guerra MM, Laborda J, Nueda ML, Baladrón V. Cells. 2020 Sep 4;9(9):2032. doi: 10.3390/cells9092032. PMID: 32899774. - Optimizing Small World Initiative service-learning by focusing on antibiotics-producing actinomycetes from soil. De Groot PWJ, Fernández-Pereira J, Sabariegos R, Clemente-Casares P, Parra-Martínez J, Cid VJ, Moreno DA. FEMS Microbiol. Lett. 2020. 366(24):fnaa019. doi: 10.1093/femsle/fnaa019.
- Deletion of GLX3 in Candida albicans affects temperature tolerance, biofilm formation and virulence. Cabello L, Gómez-Herreros E, Fernández-Pereira J, Maicas S, Martínez-Esparza MC, De Groot PWJ, Valentín E. FEMS Yeast Res. 2019. 19[2]: doi:10.1093/femsyr/foy124.
- Polymerase Activity, Protein-Protein Interaction, and Cellular Localization of the Usutu Virus NS5 Protein.
Albentosa-González L, Clemente-Casares P, Sabariegos R, Mas A. Antimicrob Agents Chemother. 2019 Dec 20;64(1):e01573-19. doi: 10.1128/AAC.01573-19. Print 2019 Dec 20. PMID: 31685463 - P53 pathway is a major determinant in the radiosensitizing effect of Palbociclib: Implication in cancer therapy.
Fernández-Aroca DM, Roche O, Sabater S, Pascual-Serra R, Ortega-Muelas M, Sánchez Pérez I, Belandia B, Ruiz-Hidalgo MJ, Sánchez-Prieto R. Cancer Lett. 2019 Jun 1;451:23-33. doi: 10.1016/j.canlet.2019.02.049. Epub 2019 Mar 11. PMID: 30872077 - HIF1α Suppresses Tumor Cell Proliferation through Inhibition of Aspartate Biosynthesis. Meléndez-Rodríguez F, Urrutia AA, Lorendeau D, Rinaldi G, Roche O, Böğürcü-Seidel N, Ortega Muelas M, Mesa-Ciller C, Turiel G, Bouthelier A, Hernansanz-Agustín P, Elorza A, Escasany E, Li QOY, Torres-Capelli M, Tello D, Fuertes E, Fraga E, Martínez-Ruiz A, Pérez B, Giménez-Bachs JM, Salinas-Sánchez AS, Acker T, Sánchez Prieto R, Fendt SM, De Bock K, Aragonés J. Cell Rep. 2019 Feb 26;26(9):2257-2265.e4. doi: 10.1016/j.celrep.2019.01.106. PMID: 30811976
- DLK proteins modulate NOTCH signaling to influence a brown or white 3T3-L1 adipocyte fate. Nueda ML, González-Gómez MJ, Rodríguez-Cano MM, Monsalve EM, Díaz-Guerra MJM, Sánchez-Solana B, Laborda J, Baladrón V. Sci Rep. 2018 Nov 16;8(1):16923. doi: 10.1038/s41598-018-35252-3. PMID: 30446682
- Food Restriction is Required to Preserve the Antisteatotic Effects of Central Leptin in the Liver of Middle-Aged Rats.Virginia López, Elena Bonzón-Kulichenko, Eduardo Moltó, Teresa Fernández-Agulló, Carmen Arribas, Antonio Andrés, and Nilda Gallardo Obesity 2018, 26(5): 877-884 First published: 25 March 2018 https://doi.org/10.1002/oby.22152 . Enlace directo al artículo http://rdcu.be/JXY2
- Molecular identification of Candida auris by PCR amplification of species-specific GPI protein-encoding genes. Ruiz-Gaitán AC, Fernández-Pereira J, Valentin E, Tormo-Mas MA, Eraso E, Pemán J, De Groot PWJ. Int. J. Med. Microbiol. 2018. 308: 812-818.
- Changes in visceral adipose tissue plasma membrane lipid composition in old rats are associated with adipocyte hypertrophy with aging.Elena Bonzón-Kulichenko, Eduardo Moltó, Cristina Pintado, Alejandro Fernández, Carmen Arribas, Dominik Schwudke, Nilda Gallardo, Andrej Shevchenko, and Antonio Andrés Journal of Gerontology: Biological Sciences & Medical Sciences 2018, First published: 16 April 2018 https://doi.org/10.1093/gerona/gly081. Enlace directo al artículo: https://academic.oup.com/biomedgerontology/advance-article/doi/10.1093/gerona/gly081/4971548?guestAccessKey=2aa05efa-b402-46a5-8737-27c938277541
- Central leptin regulates heart lipid content by selectively increasing PPAR β/δ expression. Cristina Mora, Cristina Pintado, Virginia López, Alejandro Fernández, Aurora Salamanca, Brenda Bárcena, Teresa Fernández-Agulló, Carmen Arribas, Nilda Gallardo and Antonio Andrés. Revista: Journal of Endocrinology 2018, 236: 43-56 http://dx.doi.org/10.1530/JOE-17-0554
- Central s-resistin deficiency ameliorates central inflammation and increased whole body insulin sensitivity. María Rodríguez, Cristina Pintado, Eduardo Moltó, Nilda Gallardo, Carmen Fernández-Martos, Virginia López, Antonio Andrés and Carmen Arribas. Scientific Reports 2018 Mar 2;8(1):3921.-17-34198A http://dx.doi.org/10.1038/s41598-018-22255-3 enlace directo http://rdcu.be/H9vs
- Transcriptomic immunologic signature associated with favorable clinical outcome in basal-like breast tumors.PLoS One. 2017 May 4;12(5):e0175128. doi: 10.1371/journal.pone.0175128. eCollection 2017.Martínez-Canales S et al.
- Targeting basal-like breast tumors with bromodomain and extraterminal domain (BET) and polo-like kinase inhibitors. Oncotarget. 2017 Mar 21;8(12):19478-19490. doi: 10.18632/oncotarget.14465. Nieto-Jiménez C et al.
- Mitotic read-out genes confer poor outcome in luminal A breast cancer tumors. Oncotarget. 2017 Mar 28;8(13):21733-21740. doi: 10.18632/oncotarget.15562. Pérez-Peña J et al.
- Impact of Availability of Companion Diagnostics on the Clinical Development of Anticancer Drugs.Mol Diagn Ther. 2017 Feb 28. doi: 10.1007/s40291-017-0267-y. [Epub ahead of print].Tibau A et al.
- Bioactive Flavonoids, Antioxidant Behaviour, and Cytoprotective Effects of Dried Grapefruit Peels (Citrus paradisi Macf.). Oxid Med Cell Longev. 2016;2016:8915729. doi: 10.1155/2016/8915729
- Improving green enrichment of virgin olive oil by oregano. Effects on antioxidants. Food Chem. 2016 Apr 15;197(Pt A):509-15. doi: 10.1016/j.foodchem.2015.11.002.
- Developmental study of vitamin C distribution in children’s brainstems by immunohistochemistry. Ann Anat. 2015 Sep;201:65-78. doi: 10.1016/j.aanat.2015.06.001
- Amyloid-?(25-35) Modulates the Expression of GirK and KCNQ Channel Genes in the Hippocampus. PLoS One. 2015 Jul 28;10(7):e0134385. doi: 10.1371/journal.pone.0134385
- Anatomical pathways for auditory memory II: information from rostral superior temporal gyrus to dorsolateral temporal pole and medial temporal cortex. Front Neurosci. 2015 May 18;9:158. doi: 10.3389/fnins.2015.00158
- Design of the interface of edible nanoemulsions to modulate the bioaccessibility of neuroprotective antioxidants: http://www.sciencedirect.com/science/article/pii/S0378517315004500
Novedades
Premio a Maria Alvarado ( Molecular Mycology) en el XXVII congreso nacional de la sociedad española de microbiología
Resolución de Becas Internas CRIB 2019
Resolución Provisional becas 2019_justificante

Mapping Calcium Dynamics in the Heart of Zebrafish Embryos with Ratiometric Genetically Encoded Calcium Indicators
Mapping Calcium
Visualization of Mitochondrial Ca(2+) Signals in Skeletal Muscle of Zebrafish Embryos with Bioluminescent Indicators.
Visualization of Mitochondrial
ArtículoVisualization of Mitochondrial
Publicación proclamación definitiva candidatos Director CRIB
Publicación proclamación definitiva candidatos Director CRIB PROCLAMACION DEFINITIVA CANDIDATOS DIRECTOR CRIB_signed
Publicación provisional candidatos Director CRIB
Publicación provisional candidatos Director CRIB PROCLAMACION PROVISIONAL CANDIDATOS DIRECTOR CRIB (003)_signed.
CENSO ELECTORAL ELECCIONES CRIB 2021
En virtud de lo establecido en el artículo 10 de los Estatutos del Centro Regional de Investigaciones Biomédicas y el artículo 6 del Reglamento Electoral de la Universidad de Castilla-La Mancha, aprobado por el Consejo de Gobierno el 25 de junio de 2019, y de...


