The Regional Center for Biomedical Research (CRIB, Centro Regional de Investigaciones Biomédicas) is a research center of the University of Castilla-La Mancha, which was created in July 2000 as a result of an agreement with the Ministry of Health of the Junta de Comunidades de Castilla-La Mancha, in order to promote biomedical research in Castilla-La Mancha.

The CRIB harbors 17 research groups studying various aspects of both basic and translational biomedical research. Research lines, in a multidisciplinary way, are centered on human health and its relationship to the environment in collaboration with CYTEMA -Energy and Environment Science and Technology Campus in UCLM.

The CRIB participates in the organization and delivery of official postgraduate quality teaching in biomedicine: the University Master’s Degree in Experimental Biomedicine (Biomedicina Experimental) and the Doctorate Program in Health Sciences (Verified according to R.D. 99/2011) More info

Recent publications

  • Virulence of Candida auris from different clinical origins in Caenorhabditis elegans and Galleria mellonella host models. Hernando-Ortiz A, Mateo E, Perez-Rodriguez A, de Groot PWJ, Quindós G, Eraso E.  Virulence. 2021 Dec;12(1):1063-1075. doi: 10.1080/21505594.2021.1908765. (A) 
  • Candida parapsilosis colony morphotype forecasts biofilm formation of clinical isolates. Gomez-Molero E, De-la-Pinta I, Fernandez-Pereira J, Groß U, Weig M, Quindós G, De Groot PWJ, Bader O. J Fungi (Basel). 2021 Jan 7;7(1):E33. doi: 10.3390/jof7010033.  (A)  
  • Identification of Candida auris and related species by multiplex PCR based on unique GPI protein-encoding genes. Alvarado M, Bartolomé Álvarez J, Lockhart SR, Valentín E, Ruiz-Gaitán AC, Eraso E, De Groot PWJ. Mycoses. 2021 Feb;64(2):194-202. doi: 10.1111/myc.13204. 

  • p38β (MAPK11) mediates gemcitabine-associated radiosensitivity in sarcoma experimental models. Pascual-Serra R, Fernández-Aroca DM, Sabater S, Roche O, Andrés I, Ortega-Muelas M, Arconada-Luque E, Garcia-Flores N, Bossi G, Belandia B, Ruiz-Hidalgo MJ, Sánchez-Prieto R. Radiother Oncol. 2020 Dec 11;156:136-144. doi: 10.1016/j.radonc.2020.12.008.
  • Candida duobushaemulonii: an old but unreported pathogen. Jurado-Martín I, Marcos-Arias C, Tamayo E, Guridi A, De Groot PWJ, Quindós G, Eraso E. J Fungi (Basel). 2020 Dec 17;6(4):374. doi: 10.3390/jof6040374.  

  • MicroMundo upside down: targeted searching for antibiotics-producing bacteria from soil with reverse antibiosis approaches. Alvarado M, Clemente-Casares P, Moreno DA, De Groot PWJ. Front Microbiol. 2020 Oct 15;11:577550. doi: 10.3389/fmicb.2020.577550.  

  • p38β and Cancer: The Beginning of the Road. Roche O, Fernández-Aroca DM, Arconada-Luque E, García-Flores N, Mellor LF, Ruiz-Hidalgo MJ, Sánchez-Prieto R. Int J Mol Sci. 2020 Oct 12;21(20):7524. doi: 10.3390/ijms21207524. PMID: 33053909.
  • NOTCH3 signaling is essential for NF-κB activation in TLR-activated macrophages. López-López S, Monsalve EM, Romero de Ávila MJ, González-Gómez J, Hernández de León N, Ruiz-Marcos F, Baladrón V, Nueda ML, García-León MJ, Screpanti I, Felli MP, Laborda J, García-Ramírez JJ, Díaz-Guerra MJM. Sci Rep. 2020 Sep 9;10(1):14839. doi: 10.1038/s41598-020-71810-4. PMID: 32908186.
  • NOTCH Receptors and DLK Proteins Enhance Brown Adipogenesis in Mesenchymal C3H10T1/2 Cells.
    Rodríguez-Cano MM, González-Gómez MJ, Sánchez-Solana B, Monsalve EM, Díaz-Guerra MM, Laborda J, Nueda ML, Baladrón V. Cells. 2020 Sep 4;9(9):2032. doi: 10.3390/cells9092032. PMID: 32899774.
  • Optimizing Small World Initiative service-learning by focusing on antibiotics-producing actinomycetes from soil. De Groot PWJ, Fernández-Pereira J, Sabariegos R, Clemente-Casares P, Parra-Martínez J, Cid VJ, Moreno DA. FEMS Microbiol. Lett. 2020. 366(24):fnaa019. doi: 10.1093/femsle/fnaa019.  
  • Deletion of GLX3 in Candida albicans affects temperature tolerance, biofilm formation and virulence. Cabello L, Gómez-Herreros E, Fernández-Pereira J, Maicas S, Martínez-Esparza MC, De Groot PWJ, Valentín E. FEMS Yeast Res. 2019. 19[2]: doi:10.1093/femsyr/foy124.  
  • Polymerase Activity, Protein-Protein Interaction, and Cellular Localization of the Usutu Virus NS5 Protein.
    Albentosa-González L, Clemente-Casares P, Sabariegos R, Mas A. Antimicrob Agents Chemother. 2019 Dec 20;64(1):e01573-19. doi: 10.1128/AAC.01573-19. Print 2019 Dec 20. PMID: 31685463 
  • P53 pathway is a major determinant in the radiosensitizing effect of Palbociclib: Implication in cancer therapy.
    Fernández-Aroca DM, Roche O, Sabater S, Pascual-Serra R, Ortega-Muelas M, Sánchez Pérez I, Belandia B, Ruiz-Hidalgo MJ, Sánchez-Prieto R. Cancer Lett. 2019 Jun 1;451:23-33. doi: 10.1016/j.canlet.2019.02.049. Epub 2019 Mar 11. PMID: 30872077
  • HIF1α Suppresses Tumor Cell Proliferation through Inhibition of Aspartate Biosynthesis. Meléndez-Rodríguez F, Urrutia AA, Lorendeau D, Rinaldi G, Roche O, Böğürcü-Seidel N, Ortega Muelas M, Mesa-Ciller C, Turiel G, Bouthelier A, Hernansanz-Agustín P, Elorza A, Escasany E, Li QOY, Torres-Capelli M, Tello D, Fuertes E, Fraga E, Martínez-Ruiz A, Pérez B, Giménez-Bachs JM, Salinas-Sánchez AS, Acker T, Sánchez Prieto R, Fendt SM, De Bock K, Aragonés J. Cell Rep. 2019 Feb 26;26(9):2257-2265.e4. doi: 10.1016/j.celrep.2019.01.106. PMID: 30811976
  • DLK proteins modulate NOTCH signaling to influence a brown or white 3T3-L1 adipocyte fate. Nueda ML, González-Gómez MJ, Rodríguez-Cano MM, Monsalve EM, Díaz-Guerra MJM, Sánchez-Solana B, Laborda J, Baladrón V. Sci Rep. 2018 Nov 16;8(1):16923. doi: 10.1038/s41598-018-35252-3. PMID: 30446682
  • Food Restriction is Required to Preserve the Antisteatotic Effects of Central Leptin in the Liver of Middle-Aged Rats.Virginia López, Elena Bonzón-Kulichenko, Eduardo Moltó, Teresa Fernández-Agulló, Carmen Arribas, Antonio Andrés, and Nilda Gallardo Obesity 2018, 26(5): 877-884 First published: 25 March 2018 https://doi.org/10.1002/oby.22152 . Enlace directo al artículo http://rdcu.be/JXY2
  • Molecular identification of Candida auris by PCR amplification of species-specific GPI protein-encoding genes. Ruiz-Gaitán AC, Fernández-Pereira J, Valentin E, Tormo-Mas MA, Eraso E, Pemán J, De Groot PWJ.  Int. J. Med. Microbiol. 2018. 308: 812-818 
  • Changes in visceral adipose tissue plasma membrane lipid composition in old rats are associated with adipocyte hypertrophy with aging.Elena Bonzón-Kulichenko, Eduardo Moltó, Cristina Pintado, Alejandro Fernández, Carmen Arribas, Dominik Schwudke, Nilda Gallardo, Andrej Shevchenko, and Antonio Andrés Journal of Gerontology: Biological Sciences & Medical Sciences 2018,  First published: 16 April 2018 https://doi.org/10.1093/gerona/gly081. Enlace directo al artículo: https://academic.oup.com/biomedgerontology/advance-article/doi/10.1093/gerona/gly081/4971548?guestAccessKey=2aa05efa-b402-46a5-8737-27c938277541
  • Central leptin regulates heart lipid content by selectively increasing PPAR β/δ expression. Cristina Mora, Cristina Pintado, Virginia López, Alejandro Fernández, Aurora Salamanca, Brenda Bárcena, Teresa Fernández-Agulló, Carmen Arribas, Nilda Gallardo and Antonio Andrés. Revista: Journal of Endocrinology  2018, 236: 43-56 http://dx.doi.org/10.1530/JOE-17-0554
  • Central s-resistin deficiency ameliorates central inflammation and increased whole body insulin sensitivity. María Rodríguez, Cristina Pintado, Eduardo Moltó, Nilda Gallardo, Carmen Fernández-Martos, Virginia López, Antonio Andrés and Carmen Arribas. Scientific Reports 2018 Mar 2;8(1):3921.-17-34198A http://dx.doi.org/10.1038/s41598-018-22255-3 enlace directo http://rdcu.be/H9vs
  • Transcriptomic immunologic signature associated with favorable clinical outcome in basal-like breast tumors.PLoS One. 2017 May 4;12(5):e0175128. doi: 10.1371/journal.pone.0175128. eCollection 2017.Martínez-Canales S et al.
  •  Targeting basal-like breast tumors with bromodomain and extraterminal domain (BET) and polo-like kinase inhibitors. Oncotarget. 2017 Mar 21;8(12):19478-19490. doi: 10.18632/oncotarget.14465. Nieto-Jiménez C et al.
  • Mitotic read-out genes confer poor outcome in luminal A breast cancer tumors. Oncotarget. 2017 Mar 28;8(13):21733-21740. doi: 10.18632/oncotarget.15562. Pérez-Peña J et al.
  • Impact of Availability of Companion Diagnostics on the Clinical Development of Anticancer Drugs.Mol Diagn Ther. 2017 Feb 28. doi: 10.1007/s40291-017-0267-y. [Epub ahead of print].Tibau A et al.
  • Bioactive Flavonoids, Antioxidant Behaviour, and Cytoprotective Effects of Dried Grapefruit Peels (Citrus paradisi Macf.). Oxid Med Cell Longev. 2016;2016:8915729. doi: 10.1155/2016/8915729
  • Improving green enrichment of virgin olive oil by oregano. Effects on antioxidantsFood Chem. 2016 Apr 15;197(Pt A):509-15. doi: 10.1016/j.foodchem.2015.11.002.
  • Developmental study of vitamin C distribution in children’s brainstems by immunohistochemistry. Ann Anat. 2015 Sep;201:65-78. doi: 10.1016/j.aanat.2015.06.001
  • Amyloid-?(25-35) Modulates the Expression of GirK and KCNQ Channel Genes in the Hippocampus. PLoS One. 2015 Jul 28;10(7):e0134385. doi: 10.1371/journal.pone.0134385
  • Anatomical pathways for auditory memory II: information from rostral superior temporal gyrus to dorsolateral temporal pole and medial temporal cortex. Front Neurosci. 2015 May 18;9:158. doi: 10.3389/fnins.2015.00158
  • Design of the interface of edible nanoemulsions to modulate the bioaccessibility of neuroprotective antioxidants: http://www.sciencedirect.com/science/article/pii/S0378517315004500